Disruptions in brain networks play a crucial role in the emergence of psychiatric disorders. However, translating these scientific insights into clinical practice remains a major challenge. One key reason is that the molecular and cellular causes of these changes— and thus potential targets for new therapeutic interventions—are still unknown. Our research focuses on closing this critical gap.

To achieve this, we use advanced imaging techniques in large patient cohorts to robustly identify changes in structure and function of brain networks. Translational research approaches with model organisms, cutting-edge omics methods, and artificial intelligence then provide access to the molecular and cellular levels. Our goal is to enhance the understanding of the underlying mechanisms of mental disorders, paving the way for novel treatment strategies and, where possible, bringing them into clinical application.

Close collaborations with national and international partners—such as the German Center for Mental Health (Deutsches Zentrum für Psychische Gesundheit, DZPG), the German Center for Neurodegenerative Disorders (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE), the Leibniz Institute for Neurobiology (PsychCircuits), the University of Iowa (Iowa City, IA, USA), and the Allen Institute for Brain Science (Seattle, WA, USA)—enable us to maintain an active exchange with leading research institutions worldwide. We are inspired by the vision of improving mental health and optimizing treatment and prevention strategies through fundamental research.